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KMID : 0191120140290081102
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Journal of Korean Medical Science
2014 Volume.29 No. 8 p.1102 ~ p.1107
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Acute Kidney Injury after Using Contrast during Cardiac Catheterization in Children with Heart Disease
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Hwang Young-Ju
Hyun Myung-Chul
Choi Bong-Seok
Chun So-Young
Cho Min-Hyun
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Abstract
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Acute kidney injury (AKI) is closely associated with the mortality of hospitalized patients and long-term development of chronic kidney disease, especially in children. The purpose of our study was to assess the evidence of contrast-induced AKI after cardiac catheterization in children with heart disease and evaluate the clinical usefulness of candidate biomarkers in AKI. A total of 26 children undergoing cardiac catheterization due to various heart diseases were selected and urine and blood samples were taken at 0 hr, 6 hr, 24 hr, and 48 hr after cardiac catheterization. Until 48 hr after cardiac catheterization, there was no significant increase in serum creatinine level in all patients. Unlike urine kidney injury molecule-1, IL-18 and neutrophil gelatinase-associated lipocalin, urine liver-type fatty acid-binding protein (L-FABP) level showed biphasic pattern and the significant difference in the levels of urine L-FABP between 24 and 48 hr. We suggest that urine L-FABP can be one of the useful biomarkers to detect subclinical AKI developed by the contrast before cardiac surgery.
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KEYWORD
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Acute Kidney Injury, Kidney Injury Molecule-1, Liver-type Fatty Acid-Binding Protein, Contrast
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